Present study deals with native phytotherapy among rural population in Marathwada. Marathwada region comprising seven districts. Aurangabad, Beed, Jalna, Latur, Nanded, Osmanabad and Parbhani forms the part of Vast Deccan plateau of India located 7005-7805 E longitude and 1705’ – 2005’ N longitude. The paper deals with hittherto unknown or less known medicinal uses of species recorded from rural communities of Marathwada. This forms the first ethnobotanical report from the Marathwada. Authors have collected the information about native phyutotherpy from local inhabitants from rural areas through interviews. For this Author visited villages such as Bhagwati, Tuppa, Kinwat, Renapur, Karepura, Anandwadi, Badnapur, Dharmapuri, Khadgaon, Loni, Godala, Kingaon, Sirsala, Kakhandi, Daheli, Parli-Vaijnath etc. The aim of study was to disseminate this knowledge for benefit of poor people, as plants are easily available locally. Though such a valuable knowledge has been preserved and propagated for future generation and its validity should be proved scientifically.