The Peripheral ossifying fibroma (POF), term coined by Eversole and Robin is relatively a common overgrowth which occurs exclusively on gingiva, usually arising from the interdental papilla and is considered to be reactive rather than neoplastic in nature. An origin from cells of periodontal ligament has been suggested because of exclusive occurrence of POF from interdental papilla. Because it is possible to misdiagnose POF as pyogenic granuloma, peripheral giant cell granuloma, or odontogenic tumours, therefore, histopathological examination is essential for accurate diagnosis. This paper presents a case of peripheral ossifying fibroma in a 32-year-old female involving left lower gingiva (extending buccally from mesial surface of mandibular canine to mid surface of 1st premolar) along with the clinical, histopathologic, and radiographic features and treatment details. Postoperative follow up did not show any signs of recurrence.
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