CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

The novel coronavirus is a coagulative disease with diffuse thrombosis of the vascular system: the fundamental role of the antithrombotic therapy.

Author: 
Palma Giampaolo, Imitazione Pasquale, Tarro Giulio, Polistina Giorgio Emanuele and Fiorentino Giuseppe
Subject Area: 
Health Sciences
Abstract: 

A key event in the evolution of the Covid-19 disease is represented by coagulation disorders and this is confirmed by more and more evidence and observations. Coagulopathy (CAC) associated with Covid-19 has been defined as a fulminant activation of coagulation, resulting from diffuse thrombosis, which falls within the ISTH criteria for Disseminated Intravascular Coagulation (DIC). Clinical evidence, laboratory tests, histological tests, and radiological techniques have confirmed that Covid-19 attacks not only directly the pulmonary parenchyma but is above all a "widespread systemic vascular disease affecting all organs" and not only the lungs. The coagulation disorders had already been hypothesized when in hospitalized patients, although increasing the pO2, respiratory performance did not improve because the lungs appeared "insensitive"; all this confirmed that there had to be another physio-pathological mechanism of the evolution of the disease in severe respiratory failure. The clinic chart at the patient entry to hospital for worsening dyspnea, chest pain, heart failure with evolution often in septic shock, accompanied by high coagulation indices at the entrance (D-dimer, PT, fibrinogen) and the numerous diagnoses of confirmed pulmonary thromboembolism from the chest CT Angio and numerous cardiac arrests for coronary syndromes and severe heart failure confirm the pathogenetic mechanism of hypercoagulation. The clinical manifestations of coagulation disease from Covid19 are : pulmonary thromboembolism in the lung; acute coronary syndromes (ACS) - heart failure and threatening arrhythmias in addition to heart myocarditis, stroke also in young patients with no brain comorbility, in vasculitis with increased prevalence of Kawasaki syndrome in children often asymptomatic and acute renal failures such as kidney damage and intestinal disorders such as damage to the small intestine. Therefore, therapies that have reduced considerable numbers statistically access to Intensive Care Unit (ICU) patients for assisted ventilation for severe respiratory insufficiency have proven to be the therapies that block a fundamental physio-pathological mechanism of Covid-19 disease, i.e. hyper-coagulation. and inflammation. As confirmed by the COVID departments in Italy, it was essential to block the storm of coagulation and inflammatory toxins with anticoagulants and steroids at therapeutic doses and administered at the right time to reduce access to ICU for patients. The COVID-19 disease is an endothelial disease; it is a systemic inflammation of the blood vessels that can generate serious micro-disturbances in the bloodstream and damage to the lungs, heart, brain, kidneys, and intestines. At the therapeutic level, this means that viral multiplication and inflammation must be combated but, at the same time, "it is of fundamental importance to protect the cardiovascular system of patients with drugs that act on hyper-coagulation".

PDF file: 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran