Aim: To compare and evaluate the clinical performance of Silver Amalgam and Cention-N in simple class I carious lesions in permanent molars. Methodology: After ethical approval, Patients were selected as per inclusion and exclusion criteria and Class I cavity preparation was done under rubber dam isolation and randomly divided into two groups. In Amalgam group, deep lesions were managed by application of Dycal and zinc phosphate base and restored with silver amalgam. In Cention-N group, deep lesions were treated by application of Dycal followed by Cention-N restoration. Carving was done followed by finishing and polishing. Evaluation was done at 1 week, 6 months and 1 year time interval by examiner other than operator according to modified USPHS criteria. The results of the study were tabulated and statistical analysis was done. Results: There was no statistically significant difference in the clinical performance of Silver Amalgam and Cention-N in Class I carious lesions at the end of 1 week, 6 months and 1 year. Conclusion: Both materials showed equal and acceptable clinical performance at the end of one year. Cention-N should be preferred as an alternative to amalgam in simple class I lesions.