Introduction: The interval between two surgeries is one of the important determinants of efficiency of an operation theatre. While shortening the time between two surgeries is related to efficiency, undue haste can be counterproductive as it increases risks related to infection and accident. Thus this is an optimum inter surgery period that removes unnecessary waste of time but pays extra attention. This delay can be improved by using a protocol which can improve efficiency and reduce risks. This interval is called the operation theatre changeover time. Aim: The aim of this paper is to explore the factors responsible for variations in change over time in the operation theatre related to general surgical procedures and to come up with the suggestion to optimize it. Material and Methods: Thirty instances of changeover time were captured by following general surgery patient in a general surgery operation theatre of a teaching hospital of Maharashtra. Data was collected through direct observation with the help of a checklist. Results: The average changeover time computed in general surgery operation theatre is 36.5 minutes, median 30 minutes. Whereas cleaning time is13 minutes, setup time is11 minutes and documentation time is 9 minute. Delay in clean up or set up of operation theatre for next procedure is an important factor which is one of the common reason for dissatisfaction among healthcare professionals in operation theatre.