Heavy metals pollution to water and soils due to anthropogenic activities are threats to living organisms which needs to be tackled with a new emerging technology, referred as phytoremidiation, offers a cost-effective and environmental friendly way for clean up of contaminated areas with exploitation of green plants, which either accumulates or converts it to non toxic forms, but that incurred serious physiological and metabolic constraints in plants. This review is focused on promising aspects of physiological, biochemical and molecular level to know the mechanism of plant response towards heavy metal stress.