A potent plant compound from mangifera indica to treat diabetes

Type 1.5 diabetes also known as latent autoimmune diabetes in adults (LADA) is an important form of diabetes which occurs in about 10% of patients classified as type 2 diabetes and not initially requiring insulin. β- cell dysfunction in type 1.5 diabetes is caused mainly by Glutamic acid decarboxylase antibody (GADA). β- cell stress results in an induction of Heat shock protein 90 (Hsp90) expression, where Hsp 90 is a regulator of Class II antigen processing and presentation. In silico docking studies and drug likeliness analysis have shown that docking target protein Hsp 90 α with the ligand mangiferin had a protective role against autoimmune destruction. This study paves way for treating the autoimmune diabetes at the immunity level.