Congenital heart disease (CHD) is associated with significant morbidity and mortality in pregnancy (Whittemore et al., 1982 and Shime et al., 1987). Congenital heart disease in pregnancy is associated with reduced cardiac reserve. A 24 year pregnant female 21 weeks of gestation not diagnosed to have heart disease in the past came with chief complaints of class 3 dyspnoea on exertion. On examination patient had differential cyanosis in the lower limbs, loud pulmonary component of second heart sound and parasternal heave, diagnosed to have Patent Ductus Arteriosus (PDA) with eisenmenger syndrome on Echocardiography. Laboratory investigation including complete blood picture, renal function and liver function tests were within normal limits. As mortality risk of eisenmenger syndrome is significantly high in pregnancy, termination of pregnancy was done.