Delonix elata and Prospis cineraria are used in the treatment of various diseases by local folks. Since, these plants possess many medicinal properties; the present study was designed to evaluate the phytochemicals and the antimicrobial activity of leaf extracts from of Delonix elata and Prospis cineraria. The invitro antimicrobial activity was performed by agar disc diffusion method against bacterial viz. Staphylococcus aureus, Bacillus subtillus, Klebsiella, E.coli, Proteus sp. and Pseudomonas sp. and fungi viz. Aspergillus Niger, Pencillium sp., Candida albicans. The organic extracts especially alcoholic extract, showed maximum against the micro organism. This shows that these plants can be used for medicinal purposes. Both Delonix elata and Prospis cineraria were deserved to have antimicrobial activity and can be used for medicinal purposes.