Prevalance of h-pylori in non ulcer dyspepsia in Kashmiri population

Introduction Functional dyspepsia is a common public health problem. Pathophysiology of non ulcer dyspepsia includes several possible mechanisms. Aims and objective to know the prevalence of Helicobacter pylori in non ulcer dyspepsia/ Functional dyspepsia patients through histopathological examination and rapid urease test of biopsy. Material and methods Patients with symptoms suggestive of dyspepsia and normal ultrasound findings were subjected to upper gastrointestinal endoscopy. 100 Patients having normal gastric mucosa or having features of gastritis without erosions were included in the study and subjected to biopsy from body and antrum of stomach which was studied for Helicobacter pylori by histopathological examination of specimen, rapid urease test to check for urease activity of Helicobacter pylori by using a using rapid urease test kit and was also inoculated into the medium and kept at room temperature to look for the colour change from yellow to pink. Results By histopathological examination 44 patients were positive for H. pylori and 56 were negative for H. pylori. while by rapid urease test 40 patients were positive and 60 were negative. Three patients were positive by rapid urease test alone, seven patients were positive by histopathology alone and thirty seven patients were positive by both tests. Final result was considered positive if either histopathology for H. pylori was positive or rapid urease test was positive or both were positive.. Overall 47 patients were positive for H. pylori and 53 patients were negative for H. pylori, so percentage of H. pylori positive patients was 47%. Conclusion Non-ulcer dyspepsia is a common problem encountered in clinical practice with an estimated incidence of 2-3 times more common than peptic ulcer disease. Although significant number of cases were infected with H pylori, but it cannot be concluded that H pylori is significant cause of non ulcer dyspepsia unless control group is included. Infectivity rate with H pylori was more in ulcer like subgroup were the predominant symptom is pain compared to other subgroups. So It can be concluded that non ulcer dyspeptic patients, where predominant symptom is pain, can be benefited more with H pylori eradication treatment.