Image classification has gained vital attention Investigations were carried out to determine Hepatitis B virus profile of patients in Karu, Karu Local Government Area of Nasarawa State, Nigeria. A total of three hundred and eighty four (384) blood samples comprising of two hundred and forty (240) male and one hundred and forty four (144) female were collected from patients using 5ml syringe and needle. The blood samples were dispensed into ethylene diamine tetra acetic acid (EDTA) tubes. Each sample was centrifuged at 3000 revolution per minute for 5 minutes in a centrifuge to get the plasma. Three (3) drops of each sample (plasma) was dropped into the five sample wells and results were recorded in fifteen minutes. Results showed that the highest rate of infection was from those in secondary schools with 90(48.39%) followed by tertiary institution with 78 (41.93%). Those in the tertiary institution and secondary schools were more at risk with 12(40.00%) positive HBe Ag each with the least from the adult education and no any form of education 0(00.00%). There was significant difference (p<0.005) with rate of hepatitis B virus infection between educated and uneducated individuals. Business individuals were more infected with 78(40.63%) followed by students 66(34.37%). Civil servants infected with HBV were 36(18.75%) and applicants 12(6.25%). There was no significant difference (p>0.05) between business men and their non- business counterparts. Vaccination is important in the prevention of infection with this virus. Therefore mass immunization of those not vaccinated and enlightment programs be encouraged through campaigns, seminars and workshops.