Relation of oxidative stress and seizures in epilepsy

Background: Epilepsy is a neurological disorder of brain. Oxidative stress may contribute to seizures noticed in epilepsy. The present study was taken to relate the oxidative stress role in epilepsy and also possible mechanism which may lead to further seizures and finally neuronal death noticed in Epilepsy. Aims and objectives: A total of 150 patients and 100 cases were taken in the study. All patients were diagnosed as epileptic by neurologist. Patients were categorized as Group-I (GTCS) 50 patients, group-II (JME) 50 patients and Group-III controls 50. All patients were on treatment with Anti Epileptic Drugs (AED) monotherapy and none of them are on Polytherapy i.e., 1 or 2 AEDs. Biochemical parameters MDA were analyzed by TBARS method and Total Thiols by Ellman’s method. Continuous variable with a normal distribution were expressed as means with Standard error of mean. The intergroup difference was tested using one way ANOVA test. The categorical variables were expressed as numbers with percentage. All statistical analysis was performed by using SPSS (15.0) package. A value of P <0.05 was considered as statistically significant. Results: The MDA levels were significantly increased in cases compared to controls, whereas Total Thiols were significantly decreased compared to controls with P-value <0.001. Conclusion: study reports increased oxidative stress (OS) and decreased antioxidant status, suggesting that OS has relation with seizure generation and pathophysiology of epilepsy. Treatment of Epilepsy with antioxidants, along with anti-epileptic drugs (AEDs) may help to scavenge the excessive free radicals generation in epilepsy.