Chyle is a mixture of lymph from interstitial fluid and emulsified fat from intestinal lacteals. A substantial drainage of chyle can result in severe nutritional, metabolic, hemodynamic and immunologic derangement. Hence, this article is an attempt to overview the details of: (1) Anatomy of the lymphatic duct; (2) Diagnosis of the chyleleak; and (3) Management of the chyle leakage to prevent the possible complications.