Antibiotics are chemicals that are produced by living organisms inhibit the growth or kill another organism. Most are not useful medically because of undesirable toxicity or side effects. Natural products of higher plants may be a new source of antimicrobial agents possibly with novel mechanisms of action. Tulsi (Ocimum sanctum L.) has been well documented for its therapeutic potentials. Pudina (Mentha arvensis L.) is used as a carminative, anti-spasmodic, anti peptic ulcer agent, and has been given to treat indigestion, skin diseases, coughs and colds in folk medicine.