The Living Labs approach represents a new way to address the research activities where innovations, such as new services, products or application enhancements, are validated in empirical environments within specific regional contexts. Apulia Region decided to foster this approach in Apulian ICT Living Labs and the follow-up programme Living Labs Smart Puglia 2020 to facilitate the growth and the development of Apulia SMEs specialized in the Information and Communications Technology (ICT) field, digital services and contents implementing the Apulian ICT Living Labs as a regional policy to improve ICT industry and services in the region. This paper introduces the Living Lab approach and stresses its key principles. It aims to describe how this approach has been implemented in two projects, namely ASTRO and ROBIN, which provide a humanoid robot for autism spectrum disorders (ASD) and dyslexia. The developed advanced tools for education and rehabilitation, are useful in terms of socialization of children, reducing stress due to emotional inference. Fundamental role of end users in the co-design of the learning module through computer interaction between children and robot is underlined. The module also includes a platform of learning management system, based on use of Tablet, PC, Smartphone and robotic multimedia systems for individual learning and for the contents production aimed at students with learning disabilities, in particular students with dyslexia.