According to Ayurveda, the superior vital essence of all bodily tissues is called Ojas. It is responsible for defence against diseases in human body. There are various conditions like Prameha, Pandu, Madhumeha, Shosha, Rajayakshma, Ojonirodhaka in which Ojus loss is a characteristic features. According to concept of Ojus or Bala or Vyadhikshamatva, the body resistance powers have importance in daily welfare, not only for prevention of disease but also for recovery after disease affliction. Today’s AIDS is one of such disease in which Human Immunodeficiency Virus (HIV) is causative factor leading to fight against disease. It is one of the serious global health disease. Currently there is no vaccine or cure AIDS except Anti Retroviral Therapy but it is expensive and inaccessible in many countries. Here the review article attempts to understand the concept of Ojus and HIV in scientific way and it’s over all effect on human body and it’s management according to Ayurveda like Dincharya, Ritucharya, Swasthavritta, Rasayana and Vajikarana etc.