Background: Hepcidin is a 20–, 22–, or 25–aminoacid peptide hormone, produced in the liver and detectable in serum and urine, Hepcidin controls plasma iron concentration and its increases in response to inflammatory stimuli (Weinstein et al., 2002; Nemeth & Ganz 2006). Diabetes mellitus Is a group of related diseases in which the body cannot regulate the amount of glucose in the blood, Diabetes-related chronic hyperglycemia can lead to a hypoxic environment in the renal interstitium, which results in impaired production of erythropoietin (Singh et al., 2009). Anemia of chronic disease is reflecting a reduction in red blood cell (RBC) production by the bone marrow, with a component due to mild shortening of RBC survival. A number of factors contribute to this hypoproliferative state. (Papadaki et al., 2002; Weinstein et al., 2002) Objective: The purpose of this study was to evaluate the Role of Hepcidin Level in Development of Anemia among Diabetic Sudanese Patient in Khartoum state. Materials and Methods: A total 42 patinets diagnosed with Diabetes and anemia enrolled in this study, serum was separated from participants for ELISA, to estimate hepcidin level. Results: A total 42 patients diagnosed with anemia and Diabetes, their ages ranged between (13-79) years (mean SD 45 ± 20, the mean value of hepcidin level (13.6) both male 24 (12.7%) and female 18 (14.6%) from different age groups. The mean value of blood Glucose (79.066). The hepcidin level showed correlate with duration of disease and with gender (p.value <0.05) the relation of hepicdin level. Conclusion: In summary, we conclude that serum hepcidin level has significant correlation with gender and duration of disease, so it is manly work as acute phase protein prapotinal with duration, but has no association with RBcs parameters, DM and age
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