The paper is set to establish the role of African religion in environmental conservation. Specifically, it intends to determine the role of Isukha religious beliefs and practices in the conservation of vegetation in Kakamega forest. The paper also sets out to recommend ways of disseminating African indigenous knowledge on flora. The research revealed that African religion has employed various techniques to conserve natural vegetation in the said forest. Such methods include taboos, rituals and their knowledge of sacred and profane.