Lactic acid bacteria are industrially important organisms recognized for their fermentative ability as well as their health and nutritional benefits.There is an increasing interest in these species to reveal the many possible health benefits associated with them. The actions of LAB are species and strain specific, and depend on the amount of bacteria available in the gastrointestinal tract. However, products with or processed with LAB are accepted as a natural way to preserve food and promote health. This paper aimed to review the recent data in regard to the role of probiotic LAB in food industries, in the immunomodulation in the gastrointestinal tract, and there application in its health benefits.