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Simple Convenient And Efficient Process For Removal Of Genotoxic Impurity (F Impurity) From Imatinib Api Treating With Base Using Water As Medium

Author:

Shiva Rama Krishna Samala, Kishore Gokavarapu, Srinivasa Rao B., Sarita Gokavarapu and Sunil Gandhi

Subject Area:

Life Sciences

Abstract:

A simple convenient and efficient process of Genotoxic impurity (F impurity) removal from the Imatinib API by treatment with base like sodium hydroxide at 45-50oC about 12hr using water as medium with negligible yield loss , this process can used as a high potential application in commercial scale Genotoxic impurity removal from the Imatinib API.

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