The study was conducted at Anti Retroviral Therapy (ART) centre of Susheela Tiwari Hospital, Haldwani, Distt. Nainital, Uttarakhand. The data for the study was collected by personal interview and case study. The study revealed that majority of the subject, 41.84 and 55.45 per cent were in the age group 18-30 and 30-60 years, respectively. A 77.28 per cent subjects were literate but only 10.92 per cent subjects were graduates. Heterosexual transmission was observed in 82.73 per cent subjects. Majority of subjects were on ART and only 1.81 per cent subjects were not on ART. Majority of the subjects (56.37 per cent) were diagnosed HIV infection within a period of one year while 60.18 per cent subject ART was initiated in that period. Majority (73.64 per cent) of the subjects were in I stage of infection with a mean CD4 count and Hb of 303.05±133.5 cells mm–3 and 10.88±2.15 g/dl, respectively. The mean scores of all the six domains of QOL fell in the moderate category (12.24-14.23). The subject achieved maximum score in physical domain (14.34±3.86) and minimum (12.56±2.29) in social relationship. No significant difference was found between means scores of male and female subjects. CD4 cell count was highly correlated (P<0.01) with physical and social domain.