Infection control has been one of the major concerns in the field of dentistry since decades. The dentist and his office personnel are at a great risk of contracting wide range of infections like HIV, hepatitis B, herpes, tuberculosis, respiratory diseases such as pharyngitis etc., as they are exposed to bacteria in the blood and saliva in patients routinely. There are various methods of sterilization which are commonly used like, hot air oven, autoclave, cold sterilization, etc. Orthodontists are more prone to cuts, abrasions, and puncture wounds from sharp edges of orthodontic wires, pliers and orthodontic appliances. These cuts serve as portal of entry for the bacteria which can enter the body and cause infections. In this article we have attempted to provide a brief overlook on methods of sterilization and infection control in orthodontics which can be practiced to prevent the spread of infections.