
In the present study effect of sublethal concentration of lead (0.08 and 0.10 mg/L of 96h LC50 value) on the tissue profile of Clarias gariepinus was studied. Clarias gariepinus when exposed to sublethal concentration of lead for 10 days showed various changes in the tissue parameters. The protein and carbohydrate levels were decreased in higher concentration of lead. The acid phosphatase was increased in muscle and gill but decreased in the liver. The alkaline phosphatase increased and decreased in different concentration of lead. The metallothionein levels increased in the liver, gill and muscle when compare to control samples of catfish.