Coronary heart disease has been defined as “impairment of heart function due to inadequate blood flow to the heart compared to its needs, caused by obstructive changes in the coronary circulation to the heart”. Coronary artery disease is the leading cause of death among women, regardless of race or ethnicity and causing the deaths of 1 in 3 women. Women with coronary artery disease present differently than men, have different pathophysiologies and risks profiles and are often significantly older and thus often have poorer outcomes the study was concluded at Government Coimbatore Medical College hospital, Coimbatore during September 2010 to June 2011. This study was done as a descriptive study. Hundred female patients admitted with clinical features and ECG changes and associated disease and Biochemical marks taken as cases. The following are conclusion that could be inferred from this study on clinical spectrum and risk factors among female patients. 1. The most common presentation is chest pain. 2. The most common cardiovascular sign is basal lung Crepitations. 3. Increased waist hip ratio is associated with increased risk of Myocardial Infarction in female population 4. Most of the patients with Myocardial Infarction have dyslipidaemia. 5. Diabetes Mellitus clearly related to Myocardial Infarction. 6. Hypertension also associated with Increased risk and Myocardial Infarction. 7. Sedentary habits also associated with increased risk of coronary artery disease. 8. Most common presentation is ST elevation MI. 9. Among STEMI most common type of MI is Antero septal MI. 10. OCP intake accounts for risk of obesity and MI.