Today, pharmacy profession faced street drugs, which represent both a major public health issue and a serious threat for pharmacies viability. Such situation may under certain conditions, cause non compliance pharmaceutical practices, with respect to deontology rules. Our study which consist to compare deontology rules respect by holders in urban and suburb areas, has highlighted similarities and differences on some holders behavior. Indeed, respect for personal exercise is better in suburbs where holder is present (52%) (Figure 2) and replaced at 48% (Figure 3) against 40% (Figure 2) and 32% (Figure 3) in urban areas respectively. It is the same for the respect of health educator role in suburbs (100%) (Figure 4) against (56%) (Figure 4) in urban areas. In addition, suburbs holders participate in care services and emergency at (64%) (Figure 6) against (28%) (Figure 6) in urban areas; and compliance with required uniform by suburb holders is better 48% (Figure 9), against 32% (Figure 9) in urban areas. Holders behavior is not at all influenced by geographical position of pharmacies. Therefore, it would be interesting to conduct this study specifically in suburbs, in order to understand the motivation of such behavior.