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Study Of Oxidative Stress And Transforming Growth Factor Β1 (Tgfβ1) In Type 2 Diabetic Nephropathy Of South Indian Population

Author: 
Kavitha Gandhi, Ramani Gurusamy, Priya Kalidhas and Rita Mary Aruna
Subject Area: 
Life Sciences
Abstract: 

Diabetic nephropathy is one of the commonest causes for End stage renal disease. The aim of the present clinical study was to establish whether oxidative stress and TGF-β1 may be significant in evaluating its role in variable stages of nephropathy and to determine its association with other renal parameters in type 2 diabetes mellitus patients among the south Indian population. This study was conducted on sixty patients with Type 2 Diabetes Mellitus and compared with age matched control subjects. The patients were grouped as Group I: healthy controls and Group II: Diabetic patients without nephropathy and Group III: Diabetic patients with nephropathy. Plasma TGF-β1, MDA and TAC, were measured and correlated with different biochemical parameters. Our results showed significant statistical increase in TGF-β1, MDA and MDA/TAC ratio in all diabetic patients when compared to controls (p<0.05). In addition significant difference was observed in HbA1c, TGF- β 1 and MDA among the diabetic patients with nephropathy as compared to diabetic patients’ without nephropathy. MDA showed positive correlation with TGF-β1, HbA1c and significant negative correlation with TAC among the diabetic patients. Our results suggest that diabetic patients with nephropathy and having poor glycemic control have increased level of TGF-β1 and oxidative stress. Hyperglycemia may trigger the oxidative stress in turn causes the depletion of antioxidants which up regulates the level of TGF-β1. The supplementation of antioxidants and having strict glycemic control may delay the development of renal disease in type 2 diabetes.

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