
Central Line Associated Blood Stream Infection (CLABSI) contributes to a small but significant cause of inpatient morbidity. Globally evidence based approaches are practiced to target a zero CLABSI rate. A prospective study was conducted in our hospital over a period of two years. The incidence of CLABSI was studied per 1000 central lines days for initial 5 months. This was followed by phase wise introduction of the CLABSI reduction program. When all the three interventions implemented the CLABSI rates were sustained at zero over duration of 7 months. Thus the strict implementation of Central Line bundle, Infection Control Team and Staff Education are the corner stones of safe and aseptic precautions being followed and adhered to for bringing down not just the CLABSI but also other hospital acquired infections.