Various species of mosquitoes transmit different types of disease like malaria, yellow fever, dengue fever, chikungunya, filariasis and encephalitis to more than 700 million people annually with millions of resultant deaths. The aim of the work is to evaluate larvicidal activity of Cu(II) complex against mosquito. These reduced Schiff base pyridine/ triphenyl phosphine Cu(II) complex were found to have effective against anopheles and Culex mosquito.