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Synthesis, characterization and antifungal activity of hydrazone schiff base

Author:

AmrataPawaiya, Priya Pawaiya, Sangeeta Rajput, M. C. Agrawal and R. K. Bhatnagar

Subject Area:

Physical Sciences and Engineering

Abstract:

Hydrazones derived from aromatic acid hydrazides and aromatic or heterocyclic aldehydes have a wide variety of applications in many fields. 3-aldehydosalicylic acid (3ASA) serves as precursor for the formation of hydrazone ligand. The condensation of 3-aldehydosalicylic acid with Phenyl hydrazine hydrochloride in the molar ratio 1:1 yield the corresponding hydrazone, ligand respectively. The structure of ligand was elucidated by FT-IR, 1H, NMR and mass spectrometry. The results are in consistent with bidentate chelation of ligand with azomethine nitrogen and ring nitrogen donors. The Schiff base show a significant antifungal activity against Candida albicans, Aspergillus niger, and Penicillium sp.

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