Ringworm or (dermatophytosis) is a fungal disease caused by Trichophyton verrucosum and T.mentagrophytes. It is transmitted by direct contact with infected animals or by indirect contact through fomites. Three different concentration of Calvatia craniformis mushroom ointment are prepared from mushroom powder were (0.25%,0.50% and 1%), then applied topically to lesion once daily. Sixty infected ewe, lamb in different age and sex were involved in our study and divided into two groups; the first is treatment group and, the second is the control group. The treatment group includes thirty patients which is divided into three subgroups, each subgroup include ten patients they were treated by one of the three concentrations. The control group included thirty patients was treated by 1% iodine ointment. The 1% mushroom ointment significantly reduce clearance time (P<0.05)in comparison with the control group, while other concentration produce non significant changes in clearance time, therefore this substance is effective in the treatment of ringworm with less time.
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