Levetiracetam (LEV) is a broad spectrum anti-epileptic drug with renal elimination and no hepatic metabolism. LEV is a relatively well-tolerated both in adults and children. Various behavioral and psychiatric side-effects associated with LEV is been reported. Encephalopathy can occur concomitant with levetiracetam accumulation in a patient with chronic renal failure and also when administered along with valproate. This condition like encephalopathy and psychosis are reversible after down-titration of levetiracetam with no change of the renal function. Encephalopathy resulting from LEV administration without renal dysfunction is a rare occurrence. The knowledge of these facts hold an important role in clinical practise. We hereby present two case reports enlightening the complication of LEV in different clinical scenario.