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In vivo antimalarial activity of streptomyces sp against plasmodium berghei in mice model

Author: 
Sweetline, C., Usha, R., Dhanabalan, R. and Palaniswamy, M.
Subject Area: 
Life Sciences
Abstract: 

Treatment of malarial infection has becoming extremely challenging due to widespread resistance of the parasite towards available antimalarial drugs. In the present study, we investigated the antimalarial activity of the ethanolic extracts of Streptomyces sp (KMA08) in Plasmodium berghei infected mice. The antimalarial activities during early and established infections were evaluated using Peters’ 4-day suppressive test method. Different concentration of the crude extracts were orally administered to screen for their antimalarial activities. The extracts significantly inhibited parasitemia dose-dependently. Each extract showed variable level of parasitemia suppression in dose related manner. The ethanolic extract of Streptomyces sp was found to produce 47.5% (30ml/kg) parasite suppression. The test substance observed to be safe with no toxicity on the mice even at 30 ml/kg. Results showed that significantly improved the suppression of parasitemia. The results of the present work supported the use of the Streptomyces sp against malaria and confirmed the antimalarial activity. Moreover, antimalarial compounds can be isolated and tested against human malaria parasite in the future.

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