Thiadiazoles and their derivatives demonstrate a broad spectrum of biological activities, including antibacterial, antifungal, antitubercular, antidiabetic, anti-inflammatory, anti-convulsant, and diuretic effects. In this research, several new series of 1,3,4-Thiadiazole Schiff bases were synthesized from benzoic acid reacted with thiosemicarbazide, resulting in the formation of the 5-(3-nitrophenyl)-1,3,4-thiadiazol-2-amine derivative. The free amine group at the second position of this product was altered into various Schiff bases by reacting it with diverse aromatic aldehydes to obtain the target compound. The compounds' purity was determined through TLC and enhanced via recrystallization and column chromatography. The structures were established using IR, 1H NMR, and mass spectral information. 5-(3-nitrophenyl)-1,3,4-thiadiazole -2 -amine-Schiff basesanalogues were evaluated for their antibacterial (Escherichia coli ATCC 25922) properties using the cup plate method and antitubercular activity through MABA (MicroplateAlamar Blue assay) on the H37Rv strain of Mycobacterium tuberculosis





