Instructional Design ADDIE (Analysis, Design, Development, Implementation and Evaluation) based on Flipped Classroom is presented, raising the subject “From minerals to metals: chemical processes, usage and relevance” in the Chemistry III subject at UNAM´s Colegio de Ciencias y Humanidades High School. This paper was developed in five stages: initial analysis, design, development, implementation and evaluation. During the first phase, previous knowledge and learning style tests were carried out, taking also into account motivation. For the second phase, didactic and educational materials were designed, selected and developed. Subsequently, this was implemented in 2019-I semester in a group of 17 students. When evaluated, didactic efficiency and Hake´s normalized gain were higher than 80%, indicating that the instructional design used influences positively in acquiring concepts, abilities and competencies by stimulating critical thinking, collaborative learning and self-learning.
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