Diabetes and anxiodepressive syndrom are both two mjor problem of public health who have influence for each other. Depression and anxiety are the first psychiatric problems of diabetics’ patients that are often misdiagnosed and non-treated. The aims of this study are to evaluate the prevalence of anxiety and depression and to extract the associated risk factors, in order to improve the intake of the diabetic patients. A cross-sectional, descriptive study was conducted within the endocrinology service in the University Hospital of Josph Raseta Befelatanana. Fifty diabetic patients were reported in the study, and the average age was about 27,35 years old with a female gender predominance. Depression was about 37% of the cases, and anxiety about 40%. Height percent of the study population has already made a suicide attempt in their medical history. The economic level, the comorbidity with arterial hypertension and alcool addiction were both factors that can influence in the incidence of depression and anxiety. So, the treatment of a diabetic patient should be subject to a multidisciplinary medical care.