An electrical charges status has been found in Coronavirus COVID-19 surface. As a result of this research it is possible to look for viral surface properties that may indicate with their electrical feature the possibility to be considered in the prevention as well in the therapy of patients. Vaccine designed strategy has benn already suggested for the ralationship with procoagulated effect due to the spike SARS-CoV-2 protein. Of course other approaches are being valuted as the antiviral activity of cellular glutathione.