Gain for periodontal tissues: Emdogain®, An enamel matrix derivative

Regenerative periodontal surgeries are performed to stimulate lost periodontal tissues that were affected by periodontal disease. Surgical procedures involving root conditioning, autografts, allografts, xenografts, non-bone graft materials and even barrier membranes for guided tissue regeneration (GTR) have been used successfully in regenerative procedures. Enamel matrix derivative (EMD, Emdogain®) is one such modality, which has been designated as Osteopromotive, is used to promote periodontal regeneration, consisting of a formulation of amelogenin proteins derived from six month- old piglets. Being a xenograft and its tendency for stimulating immune reaction has led to numerous studies in-vitro and in- vivo both in animals and humans. Studies have been conducted not only focusing on the safety and effectiveness but also in terms of wound healing and in combination with other regenerative materials available. Through this paper, an attempt has been made to analyze the derivative of enamel matrix, Emdogain®.