Plasma protein-C is a natural anticoagulant in our body & has inhibitory effects on factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. In Homozygous individuals it usually manifests as purpura fulminans in newborns whereas heterozygous protein C-deficient individuals are at increased risk for venous thrombosis. We are presenting a case of young male patient with heterozygous protein-C deficiency who experienced right sided hemiparesis due to cranial venous sinuses thrombosis without underlying major risk factors. Cerebrovascular accidents in young without underlying major risk factors should be evaluated for thrombophilia including protein C deficiency.
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