
Momordica charantia Linn. (M. charantia) commonly-known as karela, bitter melon, or bitter guard is tropical and subtropical areas around the world, mainly in Asia, India, China, and Brazil, where it is traditionally used as a medicinal plant, and the fruits of some varieties of M. charantia are consumed as food. Ancient days to now a day, it possesses many uses as anti-diabetic, carminative, anthelmintic, anti-malarial, anti-microbial, anti-viral, anti-carcinogenic, contraceptives, immunostimulant, laxative, antioxidant, insecticidal and also indicates in skin treatment (eczema, acne, mycoses, scabies, and hemorrhoid). Herbalism has a long tradition of use outside of conventional medicine. It is becoming more main-stream as improvements in analysis and quality control along with advances in clinical research show the value of herbal medicine in the treating and preventing disease. In this paper, we revealed the medicinal potency and pharmacological activity of M. charantia.