Background: In immune thrombocytopenic purpura (ITP) there is premature destruction of platelets in the reticuloendothelial system. Splenectomy is a treatment of choice in chronic ITP refractory to medical management. Objective: The aim of the study is to assess the response to splenectomy, venous thrombotic episodes associated with splenectomy. Methods: A retrospective cross sectional study where the data Sentence Reconstruction for ITP in appostrophe Medical college Banglore was analyzed for side effects of treatment presplenectomy; response and thrombotic episodes post splenectomy. Results: There was significant improvement in platelet count post splenectomy (p value 0.00). 36.6% patients had complete response and required no treatment after splenectomy; rest of the patient’s required medical management to maintain hemostasis. Even though venous thrombosis was high in the laparoscopic and HALS group, it was statistically insignificant (p value 0.08). Conclusion: There was significant clinical response to splenectomy in ITP patients either completely or partially. Preoperative vaccinations and proper surgical methods results in lesser infections post procedure, with statistically insignificant thrombotic episodes making splenectomy a safer treatment option.
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