Introduction: Hepatitis B infection is a common cause of chronic liver disease. The World Health Organization estimates that 257 million people are living with hepatitis B. In 2015, over 800,000 deaths worldwide were attributed to complications of hepatitis B infection. Hepatitis C virus is a globally prevalent pathogen and a leading cause of death and morbidity, is a major cause of cirrhosis and hepatocellular carcinoma. The most recent estimates of disease burden show an increase in seroprevalence over the last 15 years to 2.8%, equating to >185 million infections worldwide. Materials and Methods: This study was carried at the Department of medical biochemistry in Public Health Organization Clinical hospital d-r Trifun Panovski in Bitola. The serum was separated and HCV and HBs Ag were measured using Abbot Architect CI 4100 analyzer. Results: A total of 661 patients were examineated. The mean age of the cohort was 41 years old, ranging from 0 to 90 years old. Analysis of the results showed that 129 patients were reactive of the virus: 43 patients are HBsAg reactive (22 males and 21 females), 81 patients are anti-HCV reactive (65 males and 16 females), 4 patients are HBsAg + anti-HCV reactive (male). Discusion: In our country the rate of HCV and HBV cases is constantly increasing. This is evidenced by data from our research showing a 1% increase in cases compared to 2016. Seriously worrying is the fact that in 2018 there are 30 more patients, newly infected with hepatitis C virus. Hepatitis B virus has been proven to have several subtypes, but unfortunately it has not yet been detected in our country. Conclusion: Hepatitis B and C infections are a serious health and social problem. They affect the quality of life of the whole family, not just the person who carries the disease. It is necessary to educate the population at an early age on how to transmit and direct young people to healthy lifestyles, sports and contraceptive use.
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