Aim and Objectives: The purpose of this study was to determine the number of cases, location and types of oral lesions in patients attending OPD in Index Medical College, Hospital and Research Centre, Indore. Material & Method: The patients who came with complain of oral lesions were registered and detailed clinical data were recorded. These cases were divided in three age groups,i.e. less than 40 years of age, 40 to 60 and more than 60 years of age. The biopsy was taken and it was subjected to histopathological examination. Results: Total 70 patients were included in study who had complaint of oral lesions. Among 70 patients, 58.6% patients were diagnosed as Well Differentiated Oral Squamous Cell Carcinoma, 20% Moderately Differentiated Oral Squamous Cell Carcinoma, 8.6% Poorly Differentiated Oral Squamous Cell Carcinoma, 10% have Leukoplakia, Verrucous carcinoma and Verrucous Vulgaris 1.4% each. Conclusion: The present study shows the increasing number of oral malignant lesions, most frequently due to use of tobacco in any form and alcohol.