
Background: Cancer is seen to be the main cause for death in both developed and developing countries. A cancer diagnosis generates a higher sense of distress may lead to anxiety, depression or both. Depression is a common co- morbidity among cancer cases. Therefore, addressing the impact of depression with the help of complementary therapies is needed. In that, Zone Therapy have been doing their own fancy footwork on depression among cancer patients. It is of applying pressure to specific points in the feet, hand and ear. It helps to restore and maintain the bodies natural equilibrium. Aim: To evaluate the Effectiveness of Zone Therapy on Depression among Cancer Patients. Methods: Randomized controlled trial research design was used for this study. 50 samples were divided into 25 in experimental group who received Zone therapy and other 25 in control group who received routine treatment. Samples were selected using simple random sampling method. The data was collected, organized and analyzed in terms of both descriptive and inferential statistics. Results: The study result showed that, obtained T test value for pre test is 1.074 and post test is -3.158 and p-value is < 0.05. Conclusion: The study findings reveals that the zone therapy is effective to bring about changes in the level of depression among cancer patients in Puducherry Cancer Trust Hospital and Research Centre.