Tuberculosis is a global health problem, especially in countries that are grouped in high-burden countries, including Indonesia. Indonesia was in second position with the highest number of TB patients in the world in 2016. Based on the annual report of Medan City Health Department in 2016, succeed rate in Medan City was 73.04%. This study was conducted to determine the relationship of knowledge of pulmonary TB patients with the level of treatment adherence. uses correlational analytic design with cross sectional approach obtained 80 TB patients who had treatment in community health centers of Medan Denai District. Data were collected through interview using questionnaire and analyzed by chi-square test with 95% confidence interval. The results showed an association between patients knowledge (p=0.001) with the level of treatment adherence in the primary health center of Medan Denai District.
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