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Synthesis and ir spectroscopic characterization of some synthesized chalcone linked isatin derivatives -based schiff bases

Author: 
Chatadi Rohini, Kavya Thurai Arasan, Jagadeeshbabu, V., and Saritha, M.
Subject Area: 
Life Sciences
Abstract: 

A new efficient and environmental friendly procedure for the synthesis Chalcone linked Isatin derivatives -Based Schiff Bases under microwave irradiation method also. The method is compared with the conventional method also. A series of novel Chalcone linked isatin derivatives were investigated for anti-inflammatory related activities such as cyclooxygenase inhibition. The results also showed that the chalcone derivatives with isatin moiety seem to be significant for inhibition of enzymes. Molecular docking experiments were carried out to elucidate the molecular aspects of the observed inhibitory activities of the investigated compounds. Present study findings increase the possibility that these newly synthesized chalcone linked isatin derivatives might act as a useful starting material for the design and synthesis of improved anti-inflammatory agents and synthesized compounds were characterized by IR spectroscopy.

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