The Severe Acute Respiratory Syndrome Corona -2 (SARS-COV-2) is a highly contagious and contagious Corona virus, creating a respiratory epidemic called Corona virus disease 2019 (Covid-19) that threatens human health and public safety. On January 30.2020 the World Health Organization declared the outbreak as a global public health emergency. In these reviews we describe the basic virology of SARS-COV-2, including diagnosis, treatment. We summarize current knowledge of clinical epidemiology and clinical features of COVID-19 and immune response, disease management, control and prevention strategies, advances in the SARS COV-2 vaccine. Highlights - Critical respiratory disease, Corona virus -19, disease, diseases, public health, prevention strategies.