AIMS To study the uniqueness of Premature coronary artery disease in Indians with respect to clinical behaviour, risk factor profile, and treatment response. METHODS Registered under Clinical Trials Registry of India (CTRI/2018/03/012544). This is a Prospective Multisite Descriptive Observational study of young Indians (≤ 40yrs) with CAD from index admission till 5yrs follow-up. The clinical presentation, line of management, angiographic profile, Hospital course, and clinical follow up for next 5yrs will be documented All patients will be provided Integrated cardiology care starting at hospital admission and continued during follow up. CONCLUSION Findings may be used to form risk-prediction models for young Indians and provide longitudinal clinical follow-up data of long-term outcomes of different treatment strategies