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Triple negative breast cancer- experience at tertiary care centre, South India

Author: 
Satyanarayan V. and Ashok Akula
Subject Area: 
Health Sciences
Abstract: 

Background: Triple negative breast carcinoma (TNBC), defined as tumors negative for ER, PR and Her 2 Neu receptors with distinct clinical entity characterised by aggressive behaviour, no specific targeted therapy and poor outcome. Aims and objectives: 1. To study clinicopathological variable in TNBC 2. To study outcome of different modalities of management in TNBC. Materials and Methods: A retrospective study was conducted based on hospital records in Department of General Surgery between March 2012 and October 2014. Inclusion criteria: All female patients with breast cancer who were treated in ESIC who had triple negative harmone receptors. Exclusion Criteria: No follow up records in cancer registry. Demography, Stage of disease at presentation, Management, response to neoadjuvant chemotherapy, Grade of tumour and follow up for 20 months were analyzed, All patients underwent either modified radical mastectomy, breast conservative surgery as standard of care depending of stage of disease and anthracycline based chemotherapy was used for neoadjuvant or adjuvant setting. Results: Out of 40 cases in the study period 30 cases (75%) belonged to age less than 45 years. Thirty two patients (82%) had premenopausal status. Predominant cases were in advanced stage. Out of 16 cases who received neo-adjuvant chemotheraphy 100% response was noted with complete response rate at 13%. Infiltration ductal carcinoma was most common histology noted and 60% had grade 3 tumor. At mean follow up of 20 months, recurrence rate was noted in 11% of cases. Conclusion: TNBC patients present at early age with high grade and advanced stage. Anthracycline based chemotherapy has excelled response when used in neoadjuvant settings.

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