Ewing sarcoma (ES)/primitive neuroectodermal tumours (PNET, together defined as Ewing sarcoma [ES]) is a primary neoplasm of the skeletal system, first described by James Ewing in 1921 (Gupta et al., 2009). ES is the second most common bone cancer, most often occurring in Caucasian children, adolescents and young adults. we are presenting two cases of ewings sarcoma maxilla and one case of ewings sarcoma scapula. Ewing's sarcoma is a radiosensitive tumour (Infante-Cossio et al., 2005). Multimodality therapy consisting of an initial biopsy, aggressive combination of surgery, chemotherapy and localized radiotherapy is the treatment of choice for Ewing's sarcoma of the head and neck region and may result in long-term survival (Vikas Prasad et al., 2008). The prognosis of ES is poor because hematogenous spread and lung metastases occur within a few months after diagnosis, although the tumor burden is considered today as an important factor of prognosis (Ross et al., 2013; Regezi et al.; Davido et al., 2011; Brazão-Silva et al., 2010). Systemic disease is the most important predictive factor towards disease-free survival followed by the clinical response to chemotherapy (Zheng et al., 1998).
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