The Infective endocarditis (IE) is a rare and serious condition due to its complications classically by hematogenous spread of septic emboli to different organs. Endogenous endophthalmitis is a rare and potentially blinding ocular infection of the innereye. that occurs in the blood. We report the case of a diabetic 50-year-old woman with endogenous endophthalmitis as the first clinical manifestation of native mitral valve infective endocarditis that rapidly progressed to death. Endophthalmitis is still a rare complication but can quickly compromise the functional and vital prognosis, requiring an extremely fast and strict management.